Things you need to know about Immune checkpoint functional assays

Things you need to know about Immune checkpoint functional assays

The immune checkpoints are the costimulatory and inhibitory signals that help maintain the equilibrium between control amplitude and T cells’ immune response quality. Theimmune checkpoints are essential for keeping tissues from damage during pathogenic infection under normal physiological conditions. Changes in the immune checkpoints using monoclonal antibodies may provide healing strategies for tumor growth, autoimmune diseases, and infectious diseases and boost T cell activity.

What is Immune checkpoint assays?

The Immune checkpoint assays signal that the immune system sends for recognition of antigen via T cell receptor (TCR). This process can be divided mainly into two types:

  1. Costimulatory immune checkpoint
  2. Co-inhibitory immune checkpoint

Simply put, we can say that when the immune system detects pathogens, it has molecules that can protect the tissues from damage. Numerous immunotherapy approaches have been established from the past couple of decades to examine an individual’s immune system’s ability against tumor cells. Predominantly, antibody immunotherapies show great potential in provoking durable disease control across a broad spectrum of cancer types. With all these features, immune checkpoint antibodies gain immense popularity and consideration as a promising solution for cancer treatment.

With several years of experience, we offer a full array of immune checkpoint functional assays that help discover molecules’ potential to control immune function. We are proficient enough to provide you with multiple relevant assay endpoints to reveal the drugs’ binding and functional properties. We can offer various services, and today here we are explaining a few of them to give you a brief idea about them.

T- Cell Proliferation Assay

Various agents are available in the market that can specifically or nonspecifically induce T cell activation to produce cytokine. The cytokine receptor expression and proliferation activate the T cells. T-cell proliferation assays are easy to perform and have been extensively used to evaluate T cells’ activation, vital for future potency categorization.

Cytokine Release Assay

It is an adverse event used to release proinflammatory cytokines TNF-a, IL-6, IL-8, and IFN-c from immune cells. Based on our cutting-edge technology, we offer excellent in vitro cytokine release assay to calculate the potential for a new drug in vivo.

T-Cell Cytotoxicity Assay

The T cell cytotoxic lymphocytes play a significant role in cancer immunotherapies to eradicate tumor cells through strong immune responses. The team at Immundnz

 helps you to modulate immune effector cells that destroy tumor cells in real-time.

Mixed Lymphocyte Reaction (MLR) Assay

Furthermore, MLR assays recognize the effects of biologics or medications on T cell stimulation; it is an imperative response in the tumor microenvironment (TME). We offer many diverse types of MLR assays that help you in the drug study.

In short, our comprehensive service of immune checkpoint functional assays and Modelling Immune Response can assure our clients with the most enthralling and reproducible products, offering complete confidence for later investigations. Moreover, here at Immundnz, we will try our best to meet the regulatory guidelines. For more details, please feel free to contact us at any time.

  • 02/11/2021
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