Vaccines, Drug Delivery & Transfection
Internalisation of compounds, proteins or peptides in cells is an important method in immunologic studies. This may be relevant to studies on vaccine or drug development that require transfer of product into a target cell for expression of the product and/or activation of the cell for an immune response. The delivery of products may be carried out by carriers such as nanoparticles or viral vectors, or via active internalisation of the cell, or through cell transfection reagents.
Understand the underlying mechanism of action of your treatment or vaccine
MOA studies allow you to predict how cells will respond to a certain therapeutic substance used to treat a disease. These studies, in particular, enable the identification of off-target pathways activated by the pharmaceutical compound.
Key series of chemical reactions in which molecules in a cell work together to control cell activity and function
Investigate binding of signaling molecules (ligands) to receptors
Designing and providing customizable experimental models and assays to to study receptor binding, signalling pathways and cell function and activity
Learn how Immundnz guides vaccine, drug delivery, and transfection research.
We adopted a cell line based dendritic cell (DC) model to transfer mRNA carried by a nanoparticle carrier. Both fluorescent and non-fluorescent protein products (load) were transferred as mRNA to assess translation and availability of proteins in DCs by flow cytometry.
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