Immune Risk Assessment

Experts who help you generate critical information on immune drug safety in the pre-clinical phase that could be essential in the success of the drug.

We bring unique in vitro tissue damage assays combined with immune functional assays. These customised immune assays help assess the immune risk like adverse immune response and immunogenicity induced by or associated with a drug.

Move toward translational research and start predicting Immune Risk

Acquiring critical information on the drug immunogenic property before clinical trials could be pivotal in avoiding patient risks and attrition due to costly drug failure. We bring a comprehensive meaning to drug immunogenicity and an innovative method of assessing immunologic risk.   We emphasise the analysis of drug-induced tissue damage. The immune response generated by such damage could lead to serious drug adversity. We use an in vitro human platform analysing biomarkers of immune risk and response (adaptive) and help predict drug immunogenicity.

Drug Immunogenicity 

Conventional immunogenicity tests like ADA and ‘cytokine storm’ tests provide valuable information on drug immunogenicity. However, much of drug immunogenicity remains unclear; hence the potential of a drug to cause immunogenicity remains untested. Using our advanced in vitro models, we help in understanding dug immunogenicity.

Tissue Damage & Immune Response Studies 

At Immundnz, we use standardised and customised assays based on human cell culture systems (cell lines, primary cells) to recapitulate an in vitro immune microenvironment.

Learn how Immundnz guides Immune Risk Assessment

Vaccines against SARS-CoV-2 corona virus can be designed using the S protein, and also the entirety containing the M protein. The virus is suspected to cause cytokine storm in some patients.  What is the possibility of any of these free proteins released from the vaccine to cause a serious adverse immune response?

Find out

How do you benefit from Immune Risk Assessment?

Prediction of immune-mediated adverse drug reaction can help you avoind risk in clinical phase and to better make the translation from pre-clinical studies to humans 

  • Reduction of the number of animal tests 
  • A more robust and comprehensive immunologic profile: improved safety and risk prediction, thus reducing human health hazard risk 
  • You can terminate drug development before costly advanced stages of drug development 
  • Potential to improve drugs, generate blocking agents against immune effectors and make non-viable drugs accessible to patients 
  • Meeting changes to regulatory requirements on immunologic safety 

Looking For A Tailor-Made Solution?

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Immune Modelling & Experimental Design

Immune Risk Assessment

Tissue Damage & Cytotoxicity

Immuno-Oncology & Immunotoxicity

Inflammation & Systemic Diseases

Vaccines, Drug Delivery & Transfection

Signalling Pathways

Looking for a tailored solution?

Of course, there is no one-size-fits-all solution for most studies. Immundnz specializes in developing tailored assays to enable you to challenge the status quo in your research.

 

Some of our popular assays

To accelerate your research and deliver high-quality data, Immundnz offers a broad spectrum of standardized, proven assays that are readily available.

M1/M2 Polarisation

M1/M2 are important in studies of various therapeutic areas and biological pathways.

 

ADCP

Phagocytosis is an immunologic mechanism involved in apoptosis, necrosis, infection and tumour conditions mediated by leukocytes like macrophages, DCs, and neutrophils. 

Cytokine Release Assay

Cytokine release assay (CRA) is vital in biopharmaceutical discovery and development and life science research.

 

Dendritic Cell Maturation

Dendritic cells (DCs) are the star antigen-presenting cells (APCs) of myeloid or haematopoietic origin that play a vital role between the innate and adaptive immune systems. 

 

T Cell Differentiation

The T cell proliferation assay can be used to assess modulation of the T cell response by (immunomodulatory) compounds.

 

Immune & Protein-Based

We perform various immunologic and protein-based assays that are needed in your research or drug development.