Heart diseases or cardiovascular diseases have now become the number #1 cause of many deaths across the world. According to a report, approximately 18 million people die due to heart diseases every year. Most of the deaths happen due to heart attacks and heart strokes. People with heart disease may have a high level of lipids, glucose, and blood pressure. Besides, people who have obesity, diabetes, hypertension, genetic conditions, and bad habits like smoking and an unhealthy diet can develop heart diseases. No matter what the reason is, heart disease imposes a great burden on the health-care system.
After analysing the cases of people who died of heart diseases but did not pose any of these risk factors, researchers believed that the immune system is responsible for these deaths.
Role of the Immune System to Affect a Heart’s Functions?
When a high concentration of esterified cholesterol is present in atherosclerotic plaques, it leads to cholesterol crystallisation. Recent evidence has suggested that these cholesterol crystals in the plaque cause the immune system to release cytokines that cause inflammation, increase blood vessel injuries, and create plaque instability. These factors increase the risks of heart attacks, strokes, and death.
The immune cell receptors can identify potentially harmful molecules such as damaged DNA, cell debris, and foreign proteins. The immune cells send cytokines to lessen the risks of any threats. These cytokines are linked to coronary artery disease. They can harm if they overstimulate immune response to damage cholesterol crystals in the blood vessel walls. This overstimulation is responsible for inflammation in the layers of the blood vessel wall. It degrades the affected tissues. This response is a desired effect by the immune cells that reside in the nearby pericardial adipose tissue.
The lymphocyte cluster remains important in this adaptive immune response. They damage sensors that rapidly stimulate the immune response. These lymphocytes are the activated molecules – cytokines. Less number of these cytokines with any cholesterol medication decreases the succession of atherosclerosis and the number of heart events, involving life-threatening heart attacks. Neutrophils can induce an inflammation reaction in this degradation process with the help of phagocytes that help to resolve primary inflammation reactions as well as encourage tissue repair.
This is why phagocytosis remains significant in the entire process of understanding heart diseases and developing a medicinal solution. Researchers have constantly been working on phagocytosis assays for drug development and other research-related procedures. Immundnz helps your researchers with standard and customised assays to help you find innovative solutions to your problems. Contact our immunology CRO today!
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