Importance of Mass Spectrometry in Drug Discovery

Importance of Mass Spectrometry in Drug Discovery

Mass Spectrometry (MS) is considered an analytical method used for identifying, characterizing, and quantifying target molecules. The MS process provides rich elemental information about complex mixtures, helps in structural interpretation of unknown compounds, and makes it easy to define chemical properties and structure of pharmaceuticals and biological metabolites. The power of this technique has increased to quantitative and qualitative applications as well. With the increase in sensitivity of the MS instrument and its ability to be used with chromatographic techniques, today it is utilized for studying drugs, nucleic acids, proteins, peptides, carbohydrates, oligonucleotides, nanomedicines, and other complex biological molecules.

Mass spectrometry assists various domains in the pre-clinical immunology research including biomarker discovery, antibody characterization, quantification of biopharmaceuticals and biomarkers in biological matrices.    

Evolving Role of Mass Spectrometry in Drug Discovery                        

Mass spectrometry coupled with high-performance liquid chromatography, gas chromatography, and ion and ion mobility chromatography has increased the speed, sensitivity, and selectivity of such “hyphenated” techniques. These MS techniques have enriched the entire process of drug discovery and clinical development. Various tasks like proteomics, drug target identification, off-target drug binding sites, metabolite identification, quantification of small metabolites, the action of small molecules, and other significant purposes have now been simplified with this analytical practice.

Mass spectrometry can provide detailed information about the drug, the immune system’s regulation, and the molecular mechanism of the immune response. Mass spectrometry-based proteomics can be used to study drug-protein interaction, cellular localization, protein modification, secretion, and interaction between immune cells. 

Its ability to characterize compounds even in a complex mixture of the biological sample has provided a great victory. Besides, soft ionization, great speed, high sensitivity, and high resolution have abridged complexities that were earlier experienced during the drug discovery and development process.

Mass spectrometry helps to describe the physical properties and chemical stability of synthesized compounds. Determining the three-dimensional structure of a molecule and drug-protein interaction is a virtue of a well-designed mass spectrometry process.  

How Immundnz Can Help You With Mass Spectrometry:

Immundnz works as an immunology CRO specialist. We specialize in immune response, customized immune assays, immunogenicity testing, and tissue damage analysis for drug research and development. We consider mass spectrometry an essential part of pre-clinical immunology research to help you with your drug discovery project.

We help our clients in testing the properties and safety of their drugs by creating custom assays in our laboratory and analyzing the drug molecules and their effects. We can create in-vivo and in-vitro cell culture systems for pre-clinical drug research and development. We also help pharmaceutical companies and researchers with immune modelling, immune-oncology, Th17 assays, M1 M2 polarisation, ADCP assays, and immune risk assessment.

Contact us at +44 (0)7878279127 for more information.

  • 02/11/2020


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