Immune Checkpoint: Purpose, Mechanism, and Types

Immune Checkpoint: Purpose, Mechanism, and Types

To avoid chronic inflammation and autoimmunity and to keep the immune response in check, many types of immune signaling paths are employed. The role of these pathways is to stimulate or inhibit the immune response in order to maintain homeostasis. They are specifically designed to allow the maximum immune response to foreign antigens. They also help in preventing self-harm caused by an overreaction of the immune system. A checkpoint is one among those signals.

What Does Immune Checkpoint Stand For?

An immune checkpoint is known as a kind of signal that regulates the antigen recognition of TCR or T-cell receptors in the immune response. The checkpoint has been categorized into two parts: co-inhibitory immune response checkpoint and co-stimulatory immune checkpoint.

Cancer cells manipulate immune checkpoints for their own split ends. Similarly, checkpoints can be used to manipulate and enhance the response of the immune system against the tumor a bit easily and more effectively.

Significant Role of Checkpoints in Immune Response:

When pathogens attack the immune system, these checkpoint molecules start their work to protect the normal tissues from the damage. Immune checkpoint antibodies have gained more popularity and attention over various multiple immunotherapy approaches. This is because the use of immune check blockage in the entire immunotherapy does not keep the immune system in check and cause tissue damage by a mechanism. Cancer immunotherapy has now put more attention on bringing these checkpoints. They work miraculously to prevent negative regulation of immune response and promote positive regulatory effects. This has come up as a promising solution for cancer treatment. Also, various immune checkpoints are being targeted with this approach.

At Immundnz, we have all-embracing experience of working on a novel platform that offers a complete range of immune checkpoint assays. These assays help you to discover the potential of molecules to modulate immune functions. We are able to provide relevant assay endpoints to help you determine the binding and functional properties of the molecule. Below are the services that come under our Immundnz checkpoint-

. Dendritic cell (maturation) assay

. Th differentiation assay, Th17 assay

. T-cell activation assay

. Phagocytosis/ADCP assay/M1-M2 assay

. Cytokine secretion assay

. Mixed lymphocyte assay

. Marker expression study

. Antigen-specific T-cell activation assay

. Cell death assay / induced tissue damage

. Functional assay (gene knockdown and knock-in)

. Adhesion assay

. MTT assay

. LDH assay

. Cleaved caspase assay

. Scratch assay (wound healing)

How Can Immundnz Help You in Immune Checkpoint?

We provide a wide range of functional assays. Our immune checkpoint assays can be done through the methods of cell death analysis, antibody application testing, cell lysate, cell characterization, tissue damage assessment, in-vitro, and more. If you like to know more about our methods, we can help you with your queries. Contact us to know more.

  • 06/19/2020
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