Oncology, immuno-oncology and systemic diseases such as cardiovascular, respiratory, metabolic and autoimmune conditions are areas of therapeutic development that require advanced immunology understanding and immune based solutions. Immundnz is an immunology lab with boutique consultancy services and in depth knowledge in immune mechanisms and protein biology to provide you with the solutions you need for making better decisions on therapeutic efficacy or safety at preclinical stage.
We model and analyse immune response to:
- test the mechanism and effect of a therapeutic
- test the potential immunological risk of a therapeutic
A CRO with a Difference….
Immundnz is an immunology CRO specialised in immune modelling, immune response and tissue damage analysis, in vivo and in vitro cell culture systems for preclinical drug research and development, nanotech, medtech, cosmetics and nutrition. We are experienced scientists who will design an experimental model and use customised immune assays as well as standard assays tailored for the right solution for your problem. We will develop novel assays in our laboratory to meet your specific and unconventional need. We offer all our assays with PBMCs and with human cell lines.
Preclinical Immune Modelling
We specialise in designing, developing and experimenting preclinical models (in vitro, ex vivo and in vivo) to study biological interactions. Immune modelling is the modelling of a system to test the immune response that may be associated with an infection, a metabolite or a drug. It would be the key source to understanding the effective pathway of a therapeutic for example an oncolytic agent In immuno oncology or an inhibitor in inflammatory diseases. We emphasise on the immune modelling of a disease or a candidate therapeutic to understand:
- – if an immunotherapeutic generates the desired immune response (e.g. against tumours), or
- – if a drug targets an immune condition (e.g. autoimmunity), or– if a drug might generate an unwanted (adverse) immune response.
IMMUNE RISK ASSESSMENT
Tissue Damage Studies
Acquiring critical information on the immunogenic property of a drug prior to clinical trials could be pivotal in avoiding patient risks and attrition due to costly drug failure. We bring a comprehensive meaning to immunogenicity and an innovative method of assessing immunologic risk. We emphasise on the analysis of drug-induced tissue damage. Immune response that may be generated from such damage could lead to serious drug adversity. We use an in vitro human platform for immune response (adaptive) studies.
Immunologic, Protein based, Bioanalytical
To support preclinical research and analysis we provide various immunologic, protein based and bioanalytical assays using cell lines and primary cells. These are provided either as standard assays or as custom designed assays. The use of cell lines in initial studies offers the advantage of minimal variability. Through our assays we will help you to study drug impact on protein expression, cell to cell interaction, migration, proliferation, phagocytosis, cell death and cytotoxicity, immune functional assays using gene knockdown, lymphocyte functions, cytokine expressions, etc. Contact us for more information or READ MORE Assays
IN VITRO HUMAN SYSTEMS
We are highly experienced in mammalian and human cell cultures and offer cell culture preparation, growth and analysis to fit your needs in drug development and characterisation. We develop 2D cell cultures as well as 3D tissue models such as organoids and 3D microfluidic culture plates. We will help you study the behaviour of drug compounds in human in vitro systems for a translational purpose through a service portfolio consisting of various techniques and methods. Immunologic assays, cellular and molecular assays, flow cytometry, histology, microscopy and mass spectrometry are amongst our core technologies. With these techniques we contribute to innovative drug development, diagnostics and life sciences research.