Oncology, immuno-oncology and systemic diseases such as cardiovascular, respiratory, metabolic and autoimmune conditions are areas of therapeutic development that require advanced immunology understanding and immune based solutions. Immundnz is an immunology lab with boutique consultancy services and in depth knowledge in immune mechanisms and protein biology to provide you with the solutions you need for making better decisions on therapeutic efficacy or safety at preclinical stage.

We model and analyse immune response to:

  • test the mechanism and effect of a therapeutic
  • test the potential immunological risk of a therapeutic

Contact us at info@immundnz.com.

EXPLORE IMMUNDNZ

A CRO with a Difference….

Immundnz is an immunology CRO specialised in immune modelling, immune response and tissue damage analysis, in vivo and in vitro cell culture systems for preclinical drug research and development, nanotech, medtech, cosmetics and nutrition. We are experienced scientists who will design an experimental model and use customised immune assays as well as standard assays tailored for the right solution for your problem. We will develop novel assays in our laboratory to meet your specific and unconventional need. We offer all our assays with PBMCs and with human cell lines.

EXPERIMENTAL IMMUNOLOGY

From Design to Experiments and Readouts

We specialise in designing, developing and experimenting preclinical models (in vitro, ex vivo and in vivo) to study immune interactions. Our IMMUNE MODELLING will design the test of an immune response that may be associated with an infection, a metabolite or a drug. It would be the key source to understanding the effective pathway of a therapeutic for example an oncolytic agent in IMMUNO ONCOLOGY or an inhibitor in INFLAMMATORY DISEASES. Our expertise in experimental immunology helps to understand:

  • if an immunotherapeutic generates the desired immune response (e.g. against tumours)
  • if a drug targets an immune condition (e.g. autoimmunity)
  • if a drug might generate an unwanted (adverse) immune response

Contact us for more information or READ MORE Immune Oncology & Modelling

IMMUNE RISK ASSESSMENT

Tissue Damage Studies

Acquiring critical information on the immunogenic property of a drug prior to clinical trials could be pivotal in avoiding patient risks and attrition due to costly drug failure. We bring a comprehensive meaning to immunogenicity and innovative method of assessing immunologic risk. We emphasise on the analysis of DRUG-INDUCED TISSUE DAMAGE. Immune response that may be generated from such damage could lead to serious drug adversity. We use an in vitro human platform for immune response studies.

ASSAYS – IMMUNE and CELLULAR

To support preclinical research and analysis we provide various immunologic, protein based and bioanalytical assays using cell lines and primary cells. These are either ‘off the shelf’ standard assays or highly customised assays to fit the need of your study. We are highly experienced in co-cultures and provide various assays of –

T cells e.g. Th-differentiation, T cell activation and proliferation; Macrophages e.g. M1-M2 polarisation, phagocytosis, migration; Dendritic cells e.g. differentiation, maturation and activation; B cells e.g. activation and proliferation; NK cells, monocytes, etc.

READ MORE Assays – Immune & Protein Based

IN VITRO HUMAN SYSTEMS

TRANSLATIONAL RESEARCH

We are highly experienced in mammalian and human cultures and offer cell culture preparation, growth and analysis to fit your needs in drug development and characterisation. We develop 2D cell cultures as well as 3D tissue models. We will help you study the behaviour of drug compounds in human in vitro systems for a translational purpose to obtain the very important ‘HUMAN DATA’. Immunologic assays, cellular and molecular assays, flow cytometry, histology, microscopy and mass spectrometry are amongst our core technologies. With these techniques we contribute to innovative drug development, diagnostics and life sciences research.

Experimental studies that are unconventional and beyond the scope of standard assays