- Consultants in designing the model for immune response in in vitro and in vivo
- Laboratory experiments (in vivo and/or in vitro) to test the model
- Human in vitro systems and mammalian in vivo systems
Why is Immune Modelling Important?
You will need an immune model if developing an immunotherapeutic that is expected to function through generating an immune response (e.g. against tumours) or if the drug targets an immune condition (e.g. autoimmunity) or if the drug might generate an adverse immune response.
The adaptive immune system is a very complex system that is structured through a cascade of cells, receptors and cytokines that process, respond, initiate, memorise and deliver an immune response.
In a sterile inflammatory state, as in a drug-induced effect, the immune effectors interact with the tissue of the body to produce a cell mediated and/or antibody mediated immunity.
This is studied through appropriate immune model that is designed by immunologists with the relevant experience and insight.
How will you benefit from Immune Modelling?
Immune modelling will help you develop safer drugs. You will understand:
- What is the immunologic mechanism of the disease and why is it important?
- Can the therapeutic generate an efficient immune response?
- What is the potential immune response to the therapeutic, and is it important?
A good immune model in a study is very important to understand the immunology of a drug and to get the proper immunotoxicology profile.
Immundnz will help you with the proper immune insight in modelling and carrying out the experimental work in our laboratory.
To study the role of heat shock proteins in immune mediated cell death and autoimmunity a model of diabetes was designed that consisted of transgenic expression of the target protein. Cell death of islet beta cells was initiated in a controlled dose dependent manner. The study successfully revealed that the (i) the initial beta cell death was responsible for the initiation of an immune mediated diabetes, and (ii) the immune response was increased by the over expression of heat shock protein. This study was important to understand the role of heat shock proteins in immunogenicity following tissue damage.