SPECIALISTS IN EXPERIMENTAL IMMUNOLOGY & CUSTOMISED SERVICES
FOR YOUR IMMUNOLOGY SOLUTIONS IN PRECLINICAL DRUG DISCOVERY
Defining Immunogenicity Differently and Comprehensively
Moving forward into Disease Modelling and Translational Toxicology
Oncology, immuno-oncology and systemic diseases such as cardiovascular, respiratory, metabolic and autoimmune conditions are areas of therapeutic development that require advanced immunology understanding and immune based solutions. Immundnz is an immunology lab with boutique consultancy services and in depth knowledge in immune mechanisms and protein biology to provide you with the solutions you need for making better decisions on therapeutic efficacy or safety at preclinical stage.
We model and analyse immune response to:
- test the mechanism and effect of a therapeutic
- test the potential immunological risk of a therapeutic
A CRO with a Difference….
Immundnz is an immunology CRO specialised in immune modelling, immune response and tissue damage analysis, in vivo and in vitro cell culture systems for preclinical drug research and development. We are different because we are experienced scientists who will design an experimental model and use customised assays as well as standard assays tailored for the right solution for your problem. We will develop novel assays in our laboratory to meet your specific and unconventional need.
Contact us for more information.
PRECLINCAL DISEASE MODELLING
We provide our expertise in preclinical disease modelling using in vivo and/or in vitro systems. Immune modelling is the modelling of a system to test the immune response that may be associated with an infection, a metabolite or a drug. In immuno oncology it would be the key source to understanding the effective pathway of a therapeutic for example an oncolytic agent. We emphasise on the immune modelling of a disease or a candidate therapeutic to understand:
- if an immunotherapeutic generates the desired immune response (e.g. against tumours), or
- if a drug targets an immune condition (e.g. autoimmunity), or
- if a drug might generate an unwanted (adverse) immune response.
We are consultants in designing the model for immune response (in vitro and in vivo) and we will carry out laboratory experiments (in vivo and/or in vitro) to test the model. Our experience comes from years of experience in in vivo and in vitro immune modelling and protein biology in understanding disease mechanisms.
To describe a process mathematically our models can also be combined with mathematical modelling using quantitative parameters and equations to return explicit numerical behaviour that can be compared with the result of experiment.
Preclinical Immune Risk Assessment
Acquiring critical information on the immunogenic property of a drug prior to clinical trials could be pivotal in avoiding patient risks and attrition due to costly drug failure. Immundnz brings a very different meaning to immunogenicity and an innovative method of analysing immunologic risk. Within the context of immunotoxicology, our preclinical tests provide translational data based on novel biomarkers of immune response that can be predictive of drug immunogenicity. Comprehensive In Vitro Human Immune Response Testing of drug compounds, COMPIT, is a human in vitro platform developed by Immundnz that enables the preclinical study of drug-induced immunogenicity and the risk of immune mediated pathology.
We will tell you why the market has only a partial view of drug immunogenicity and how obtaining a more comprehensive information on immunogenicity is necessary to generate safer and viable drugs.
Through our system of human cells you will know if your drug has the potential to cause damage to human organs with the possibility of an immune mediated pathology before it enters clinical trials. COMPIT is a preclinical system that can be applied to small molecules and large molecules.
IMMUNOLOGIC, PROTEIN BASED & BIO-ANALYTICAL
To support preclinical research and analysis we provide various immunologic, protein based and bioanalytical assays. These are provided either as standard assays or as custom designed assays. Through our assays we will help you to study drug impact on protein expression, cell to cell interaction, migration, proliferation, cell death and cytotoxicity, functional assays using gene knockdown, lymphocyte functions, cytokine expressions, etc. Contact us for more information or READ MORE Assays – Immune & Protein Based.
In Vitro Human Systems
We are highly experienced in mammalian and human cell cultures and offer cell culture preparation, growth and analysis to fit your needs in drug development and characterisation. We develop 2D cell cultures as well as 3D tissue models such as organoids and 3D microfluidic culture plates. We will help you study the behaviour of drug compounds in human in vitro systems for a translational purpose through a service portfolio consisting of various techniques and methods. Immunologic assays, cellular and molecular assays, flow cytometry, histology, microscopy and mass spectrometry are amongst our core technologies. With these techniques we contribute to innovative drug development, diagnostics and life sciences research. Contact us for more information or READ MORE In Vitro Human Systems.